Within EU cohesion policy, a place-based approach is expected to promote a strategic shift towards more place-sensitive, cross-sectoral and socially inclusive development. These expectations are underlined in the new Territorial Agenda 2030, which highlights that a place-based approach is key to territorial cohesion and to overall efforts towards a just Europe. Drawing on findings from the Horizon 2020 project RELOCAL – Resituating the local in cohesion and territorial development – this special issue explores the relations between place-based development and spatial justice. It addresses the complex challenges of place-based interventions, such as the critical role of the national policy environment in explaining variegated outcomes, enabling place-based agency in peripheralised regions, and assessing impacts. In this editorial, we provide an introductory discussion of the relations between place-based development and spatial justice, as well as brief introductions to the nine papers. We argue that there are a number of distinctive locally and nationally anchored mechanisms and inhibitors at play, which academics, and particularly planning professionals and policy-makers, need to be aware of in working towards a just Europe. Hence, place-based interventions are a valuable contribution to the territorial cohesion approach of the EU, but in the quest for spatial justice they cannot replace a redistributive territorial cohesion policy.