This paper explores Cavendish's argument for what she calls animate matter. Her commitment to the ubiquity of animate matter, styled Cavendish's animism, is presented as the conclusion of an inference to the best explanation of nature's order. The reconstruction of Cavendish's argument begins with an examination of the relationship between God's creation of our world and the order produced through nature's wise governance of her parts. Cavendish's materialism and anti-atomism are presented as ingredients in her final account of God's ordering of the world by making it a self-moving whole. On the present account of Cavendish's metaphysics, this self-moving whole then freely produces the regular motions that constitute its ordering of itself, as a distinct ordering beyond God's initial act of creating our world. The depth of Cavendish's commitment to the animistic elements of her materialism-or in other words, the extent to which her system is genuinely animistic-is then considered.