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Determination of the dose-response relations of thoracic and cervical myelopathy after external beam radiation therapy
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
2007 (English)In: 9th Biennial ESTRO Meeting on Physics and Radiation Technology for Clinical Radiotherapy, Barcelona, Spain, 9-13 September 2007, 2007Conference paper, Published paper (Other academic)
Abstract [en]

Following our previous experience, the relative seriality model

was fitted to two different sets of clinical data for radiation myelitis concerning thoracic spinal cord after radiation treatment of 43 patients with lung carcinoma and cervical spinal cord after treating 248 patients for malignant disease of head and neck.

Individual treatment data were suitably fitted by the relative seriality model. The estimated radiobiological parameters of the model indicate that the probability of inducing this complication after radiation therapy is volume dependent only for the cervical part of spinal cord, whereas for the thoracic part no volume effect could be observed.

Two different statistical methods applied to the patient material showed that the radiobiological model and the estimated parameters can be used to closely predict the complication rates observed.

Place, publisher, year, edition, pages
2007.
Identifiers
URN: urn:nbn:se:su:diva-10889OAI: oai:DiVA.org:su-10889DiVA: diva2:177408
Available from: 2008-01-08 Created: 2008-01-08Bibliographically approved

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