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Cellular parameters for track structure modeling of radiation hazard in space.
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
2004 (English)In: Adv Space Res, ISSN 0273-1177, Vol. 34, no 6, 1378-82 p.Article in journal (Refereed) Published
Abstract [en]

Based on irradiation with 45 MeV/u N and B ions and with Co-60 c rays, cellular parameters of Katz’s track structure model

have been fitted for the survival of V79-379A Chinese hamster lung fibroblasts. Cellular parameters representing neoplastic

transformations in C3H10T/1/2 cells after their irradiation with heavy ion beams, taken from earlier work, were also used to model

the radiation hazard in deep space, following the system for evaluating, summing and reporting occupational exposures proposed in

1967 by a subcommittee of NCRP. We have performed model calculations of the number of transformations in surviving cells, after

a given fluence of heavy charged particles of initial energy 500 MeV/u, penetrating thick layers of cells. We take the product of cell

transformation and survival probabilities, calculated along the path lengths of charged particles using cellular survival and transformation

parameters, to represent a quantity proportional to the ‘‘radiation risk factor’’ discussed in the NCRP document. The

‘‘synergistic’’ effect of simultaneous charged particle transfers is accounted for by the ‘‘track overlap’’ mode inherent in the model of


Place, publisher, year, edition, pages
2004. Vol. 34, no 6, 1378-82 p.
Keyword [en]
Animals, Carbon, Cell Line, Cell Survival/*radiation effects, Cell Transformation; Neoplastic/*radiation effects, Cosmic Radiation, Cricetinae, Cricetulus, Dose-Response Relationship; Radiation, Extraterrestrial Environment, Fibroblasts, Heavy Ions, Hydrogen, Iron, Linear Energy Transfer, Lung/cytology/radiation effects, Models; Biological, Nuclear Physics, Uranium
URN: urn:nbn:se:su:diva-11214PubMedID: 15881778OAI: diva2:177733
Available from: 2008-01-10 Created: 2008-01-10 Last updated: 2011-01-12Bibliographically approved

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