An enantioselective route to alpha-methyl carboxylic acids via metal and enzyme catalysis
2007 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 9, no 24, 5095-5098 p.Article in journal (Refereed) Published
Dynamic kinetic resolution of allylic alcohols to allylic acetates followed by copper-catalyzed allylic substitution gave alkenes in high yields and high optical purity. Subsequent oxidative C-C double bond cleavage afforded pharmaceutically important alpha-methyl substituted carboxylic acids in high ee.
Place, publisher, year, edition, pages
2007. Vol. 9, no 24, 5095-5098 p.
IdentifiersURN: urn:nbn:se:su:diva-11741DOI: 10.1021/ol702261tISI: 000250975000042OAI: oai:DiVA.org:su-11741DiVA: diva2:178260