Direct catalytic asymmetric three-component Mannich reactions with dihydroxyacetone: enantioselective synthesis of amino sugar derivatives
2008 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 49, no 5, 803-807 p.Article in journal (Refereed) Published
Highly enantioselective, amino acid-catalyzed, one-pot three-component asymmetric Mannich reactions between dihydroxyacetone, p-anisidine, and aldehydes are presented. The reactions proceeded with high chemo- and stereoselectivity and furnished the corresponding α,α′-dihydroxy-β-aminoketones in high yields with 82–95% ee.
Place, publisher, year, edition, pages
2008. Vol. 49, no 5, 803-807 p.
IdentifiersURN: urn:nbn:se:su:diva-13153DOI: 10.1016/j.tetlet.2007.11.196ISI: 000253170200014OAI: oai:DiVA.org:su-13153DiVA: diva2:179673