Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup.
2005 (English)In: Topics in Magnetic Resonance Imaging, ISSN 0899-3459, Vol. 16, no 6, 427-437 p.Article in journal (Other (popular science, discussion, etc.)) Published
BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.
Place, publisher, year, edition, pages
2005. Vol. 16, no 6, 427-437 p.
MRI, dementia, Alzheimer, diagnostic tool
IdentifiersURN: urn:nbn:se:su:diva-13546PubMedID: 17088692OAI: oai:DiVA.org:su-13546DiVA: diva2:180066