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Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup.
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2005 (English)In: Topics in Magnetic Resonance Imaging, ISSN 0899-3459, Vol. 16, no 6, 427-437 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.

Place, publisher, year, edition, pages
2005. Vol. 16, no 6, 427-437 p.
Keyword [en]
MRI, dementia, Alzheimer, diagnostic tool
National Category
URN: urn:nbn:se:su:diva-13546PubMedID: 17088692OAI: diva2:180066
Available from: 2008-04-10 Created: 2008-04-10 Last updated: 2011-01-12Bibliographically approved

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Almkvist, Ove
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Department of Psychology

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