Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults.
2007 (English)In: Journal of Gerontology: Psychological Sciences, ISSN 1079-5014, Vol. 62B, no 2, P112-P118 p.Article in journal (Refereed) Published
We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon 4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation In normal cognitive aging.
Place, publisher, year, edition, pages
2007. Vol. 62B, no 2, P112-P118 p.
vascular risk factors, e4 allele, Alzheimer's disease, cognitive decline, APOE genotype, serum cholesterol, declarative memory, prospective cohort, blood pressure, population
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-14722ISI: 000253835700007PubMedID: 17379671OAI: oai:DiVA.org:su-14722DiVA: diva2:181242
The Betula Longitudinal Study is funded by the Bank of Sweden Tercentenary Foundation (Grant 1988-0082:17), the Swedish Council for Planning and Coordination of Research (Grants D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, and B1999-474), the Swedish Council for Research in the Humanities and Social Sciences (Grant F377/1988-2000), and the Swedish Council for Social Research (1998-1990: Grants 88-0082 and 311/1991-2000). The Fund for Scientific Research Flanders and the Special Research Fund of the University of Antwerp, Belgium supported the APOE genotyping.
Marc Cruts is a postdoctoral fellow at the The Fund for Scientific Research Flanders. Cindy de Frias was supported by a postdoctoral fellowship from the Canadian Institutes of Health Research and is now an Assistant Professor at the Department of Psychiatry and Behavioral Science, SUNY Stony Brook. We acknowledge the contribution by the staff in the Betula project.2008-10-282008-10-282009-08-07Bibliographically approved