Catalytic asymmetric synthesis of the docetaxel (Taxotere) side chain: organocatalytic highly enantioselective synthesis of esterification-ready alpha-hydroxy-beta-amino acids
2008 (English)In: Tetrahedron Letters, ISSN 0040-4039, Vol. 49, no 47, 6631-6634 p.Article in journal (Refereed) Published
A highly enantioselective catalytic route to protected β-amino-α-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected α-oxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr and 99–99% ee.
Place, publisher, year, edition, pages
2008. Vol. 49, no 47, 6631-6634 p.
IdentifiersURN: urn:nbn:se:su:diva-15773DOI: 10.1016/j.tetlet.2008.09.038ISI: 000260944900008OAI: oai:DiVA.org:su-15773DiVA: diva2:182293