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Increasing CSF phospho-tau levels during cognitive decline and progression to dementia
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2008 (English)In: Neurobiology of Aging, ISSN 0197-4580, Vol. 29, no 10, 1466-1473 p.Article in journal (Refereed) Published
Abstract [en]

Background: Little is known about longitudinal changes of cerebrospinal fluid (CSF) biomarkers during cognitive decline in neurodegenerative disease progression.

Objective: To investigate longitudinal changes in CSF biomarkers – total-tau (T-tau), phospho-tau (P-tau) and β-amyloid (Aβ42) – during cognitive decline.

Methods: Forty memory clinic patients (47.5% females), aged 61.3 ± 7.6 (S.D.) years, non-demented at baseline, underwent lumbar puncture and neuropsychological testing at two occasions. Baseline mean MMSE-score was 28.3 ± 1.8. Patients were divided into three groups based on baseline memory functioning; severely impaired (SIM), moderately impaired (MIM) and no impairment (NIM).

Results: There was a significant increase in P-tau in the SIM-group during follow-up, while P-tau in MIM and NIM did not change. Eighty-three percent of the SIM-patients converted to dementia (80% AD), while most MIM- and NIM-patients remained non-demented. T-tau- and Aβ42-levels did not change in any of the memory groups during follow-up.

Conclusion: Increasing P-tau levels during cognitive decline and conversion to dementia suggest that P-tau may be useful as a longitudinal marker of the neurodegenerative process.

Place, publisher, year, edition, pages
2008. Vol. 29, no 10, 1466-1473 p.
Keyword [en]
episodic memory, RAVLT, MCI, dementia, longitudinal, cognitive decline, CSF biomarkers
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URN: urn:nbn:se:su:diva-17372DOI: doi:10.1016/j.neurobiolaging.2007.03.027PubMedID: 17512092OAI: diva2:183893
This work was supported by grants from the Health Care Sciences postgraduate school at Karolinska Institutet, Gun and Bertil Stohnes Foundation, Gamla Tjänarinnor Foundation, Karolinska Institutet Foundation and ALF grant 20050184. MEJ was supported by Swedish Brain Power.Available from: 2009-01-14 Created: 2009-01-14 Last updated: 2011-01-10Bibliographically approved

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