PET imaging of amyloid deposition in patients with mild cognitive impairment
2008 (English)In: Neurobiology of Aging, ISSN 0197-4580, Vol. 29, no 10, 1456-1465 p.Article in journal (Refereed) Published
It is of great clinical value to identify subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed with MCI (mean age 63.3 ± 7.8 (S.D.) years) underwent PET studies with 11C-PIB, and 18F-fluoro-deoxy-glucose (FDG) to measure cerebral glucose metabolism, as well as assessment of cognitive function and CSF sampling. Reference group data from 27 AD patients and 6 healthy controls, respectively, were used for comparison. The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. Seven MCI patients that later at clinical follow-up converted to AD (8.1 ± 6.0 (S.D.) months) showed significant higher PIB retention compared to non-converting MCI patients and HC, respectively (ps < 0.01). The PIB retention in MCI converters was comparable to AD patients (p > 0.01). Correlations were observed in the MCI patients between PIB retention and CSF Aβ1-42, total Tau and episodic memory, respectively.
Place, publisher, year, edition, pages
2008. Vol. 29, no 10, 1456-1465 p.
mild cognitive impairment, converters, amyloid, PET, PIB, FDG, CSF biomarkers
IdentifiersURN: urn:nbn:se:su:diva-17377DOI: doi:10.1016/j.neurobiolaging.2007.03.029ISI: 000258817700002PubMedID: 17499392OAI: oai:DiVA.org:su-17377DiVA: diva2:183898
Financial support from the Swedish Research Council (project 05817, A.N.), the foundation for Old Servants (A.N.), Stohne's foundation (A.N.), the KI foundations (A.N.), the Alzheimer Foundation in Sweden (A.N.), Swedish Brain Power (A.N., B.L.), the EC-FP5-projec tNCI-MCI and the EC-FP6-project DiMI, LSHB-CT-2005-512146, QLK6-CT-2000-00502 (A.N.) is gratefully acknowledged.2009-01-142009-01-142011-01-10Bibliographically approved