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A novel cyanobacterial toxin (BMAA) with potential neurodegenerative effects
Stockholm University, Faculty of Science, Department of Botany.
Stockholm University, Faculty of Science, Department of Botany.
Stockholm University, Faculty of Science, Department of Botany.
Stockholm University, Faculty of Science, Department of Botany.
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2008 (English)In: Plant Biotechnology, ISSN 1342-4580, E-ISSN 1347-6114, Vol. 25, no 3, 227-232 p.Article in journal (Refereed) Published
Abstract [en]

The non-protein amino acid beta-N-methyl-amino-L-alanine (BMAA) is a neurotoxin that was recently found to be produced by most cyanobacteria. The neurotoxin was discovered in 1967 in the seeds of the cycad Cycas micronesica, but this BMAA may originate from the symbiotic cyanobacterium Nostoc, which inhabits the roots of cycads. BMAA is thought to be the cause of the deadly neurodegenerative disease amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), common among the Chamorro people of Guam. It was demonstrated that the Chamorros, in all probability, have been exposed to high levels of BMAA through dietary consumption of flying foxes which fed mainly on cycads seeds. BMAA production may be a common conserved evolutionary feature among cyanobacteria and due to their wide global distribution, the toxin may be a common concern and potentially involved in provoking degenerative diseases worldwide. BMAA may likewise be bioaccumulated in other cyanobacterial based food webs within ecosystems outside Guam, and it is proposed that such webs may exist in the Baltic Sea, with its massive occurrence of cyanobacteria (blooms).

Place, publisher, year, edition, pages
2008. Vol. 25, no 3, 227-232 p.
Keyword [en]
beta-N-methyl-amino-L-alanine (BMAA), cyanobacteria, Baltic Sea, amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC), symbiosis
National Category
Biological Sciences
Research subject
Plant Physiology
Identifiers
URN: urn:nbn:se:su:diva-17895DOI: 10.5511/plantbiotechnology.25.227ISI: 000262639800005OAI: oai:DiVA.org:su-17895DiVA: diva2:184416
Conference
Colloquium on Frontiers in Plant Biotechnology , Stockholm, Sweden, October 4, 2007
Available from: 2009-01-22 Created: 2009-01-22 Last updated: 2015-07-20Bibliographically approved

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Jonasson, SaraEriksson, JohanBerntzon, LottaRasmussen, UllaBergman, Birgitta
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