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Membrane topology of the STT3 subunit of the oligosaccharyl transferase complex
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2005 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 280, no 21, 20261-20267 p.Article in journal (Refereed) Published
Abstract [en]

The highly conserved membrane protein STT3 is part of the oligosaccharyl transferase complex in the endoplasmic reticulum of eukaryotic cells. Various experimental observations strongly suggest that STT3 contains the active site of the complex. Here, we report a detailed topology study of STT3 from two different organisms, Saccharomyces cerevisiae and mouse, using in vivo and in vitro topology mapping assays. Our results suggest that STT3 has 11 transmembrane helices and an overall N-cyt-C-lum orientation.

Place, publisher, year, edition, pages
2005. Vol. 280, no 21, 20261-20267 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:su:diva-18940DOI: 10.1074/jbc.M412213200ISI: 000229242000014PubMedID: 15781470OAI: oai:DiVA.org:su-18940DiVA: diva2:185463
Available from: 2007-12-27 Created: 2007-12-27 Last updated: 2017-12-13Bibliographically approved

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von Heijne, GunnarNilsson, IngMarie
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