Identifying patients at high and low risk for cognitive decline using Rey Auditory Verbal Learning test among middle-aged memory clinic out-patients.
2006 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, Vol. 21, 251-259 p.Article in journal (Refereed) Published
Objectives: To investigate whether application of cutoff levels in an episodic memory test (Rey Auditory Verbal Learning Test, RAVLT) is a useful method for identifying patients at high and low risk of cognitive decline and subsequent dementia. Methods: 224 patients with memory complaints (mean age = 60.7 years, mean MMSE = 28.2) followed-up at a memory clinic over 3 years were assigned retrospectively to one of three memory groups from their baseline results in RAVLT [severe (SIM), moderate (MIM) or no impairment (NIM)]. These groups were investigated regarding cognitive decline. Results: Patients assigned to SIM showed significant cognitive decline and progressed to dementia at a high rate, while a normal performance in RAVLT at baseline (NIM) predicted normal cognition after 3 years. Patients with MIM constituted a heterogeneous group; some patients deteriorated cognitively, while the majority remained stable or improved. Conclusions: The application of cutoff levels in RAVLT at baseline showed that patients with severely impaired RAVLT performance were at a high risk of cognitive decline and progression to dementia, while patients with normal RAVLT results did not show cognitive decline during 3 years. Furthermore, the initial degree of memory impairment was decisive in the cognitive prognosis 3 years later.
Place, publisher, year, edition, pages
2006. Vol. 21, 251-259 p.
memory, cognitive decline, dementia, Rey Auditory Verbal Learning Test, RAVLT
IdentifiersURN: urn:nbn:se:su:diva-19357OAI: oai:DiVA.org:su-19357DiVA: diva2:185881