Olfactory functions in asymptomatic carriers of the Huntington disease mutation.
2006 (English)In: Journal of Clinical and Experimental Neuropsychology, ISSN 1380-3395, Vol. 28, no 8, 1373-1380 p.Article in journal (Refereed) Published
Huntington’s disease (HD) is a neurodegenerative disorder initially affecting the basal ganglia and especially the head of the caudate nucleus. Neuropsychological research has indicated that olfactory dysfunction may appear early in HD, prior to the onset of significant motor or cognitive dysfunction. The aim of this study was to examine whether asymptomatic carriers of the Huntington disease mutation also exhibit olfactory dysfunction. To address this issue we presented an extensive olfactory test battery comprising tasks assessing olfactory sensitivity, intensity discrimination, quality discrimination, episodic odor memory, and odor identification, to a group of gene carriers and non-mutation carriers of the disease. The results showed that gene carriers were selectively impaired in discriminating odor quality, although performance did not differ from non-carriers across the other tasks. The role played by striatum and then in particular the caudate nucleus for olfactory processing in general, and for odor quality discrimination in particular, is discussed.
Place, publisher, year, edition, pages
2006. Vol. 28, no 8, 1373-1380 p.
olfactory functions, asymptomatic carriers, Huntington, genetic, olfaction, neurodegenerative diseases
IdentifiersURN: urn:nbn:se:su:diva-19426DOI: 10.1080/13803390500473746OAI: oai:DiVA.org:su-19426DiVA: diva2:185950
The research was supported by a grant from the Swedish Research Council (No: F0647/2001) to Dr Maria Larsson and by grants from the Swedish Association of Neurologically disabled (NHR), Erik and Edith Fernstroms Foundation for Medical Research and Alzheimer Foundation, Sweden, to Dr Tarja-Brita Robins Wahlin.2007-11-122007-11-122016-06-22Bibliographically approved