Change search
ReferencesLink to record
Permanent link

Direct link
Regional variability in the prevalence of cerebral white matter lesions: An MRI study in 9 European countries (CASCADE).
Show others and affiliations
2006 (English)In: Neuroepidemiology, ISSN 0251-5350, Vol. 26, no 1, 23-29 p.Article in journal (Refereed) Published
Abstract [en]

White matter lesions (WML) on MRI of the brain are common in both demented and nondemented older persons. They may be due to ischemic events and are associated with cognitive and physical impairments. It is not known whether the prevalence of these WML in the general population differs across European countries in a pattern similar to that seen for coronary heart disease. Here we report the prevalence of WML in 1,805 men and women drawn from population-based samples of 65- to 75-yearolds in ten European cohorts. Data were collected using standardized methods as a part of the multicenter study CASCADE (Cardiovascular Determinants of Dementia). Centers were grouped by region: south (Italy, Spain, France), north (Netherlands, UK, Sweden), and central (Austria, Germany, Poland). In this 10-year age stratum, 92% of the sample had some lesions, and the prevalence increased with age. The prevalence of WML was highest in the southern region, even after adjusting for differences in demographic and selected cardiovascular risk factors. Brain aging leading to disabilities will increase in the future. As a means of hypothesis generation and for health planning, further research on the geographic distribution of WML may lead to the identification of new risk factors for these lesions.

Place, publisher, year, edition, pages
2006. Vol. 26, no 1, 23-29 p.
Keyword [en]
regional variability, white matter lesion, epidemiology, cardiovascular, multicenter study, geriatric patients, CASCADE
National Category
URN: urn:nbn:se:su:diva-19432DOI: doi:10.1159/000089233OAI: diva2:185956
Available from: 2007-11-12 Created: 2007-11-12 Last updated: 2011-01-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nilsson, Lars-Göran
By organisation
Department of Psychology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link