Parietal cortex activation predicts longitudinal memory decline in APOE ε4 carriers.
2006 (English)In: NeuroReport, no 17, 1683-1686 p.Article in journal (Other (popular science, discussion, etc.)) Published
Apolipoprotein E-epsilon 4 is the main known genetic risk factor for Alzheimer’s disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer’s disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at- risk persons. We studied nondemented apolipo-protein E-epsilon 4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon 4 carriers, and hence likely progression to Alzheimer’s disease.
Place, publisher, year, edition, pages
2006. no 17, 1683-1686 p.
genetics, fMRI, memory
IdentifiersURN: urn:nbn:se:su:diva-19434OAI: oai:DiVA.org:su-19434DiVA: diva2:185958