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Parietal cortex activation predicts longitudinal memory decline in APOE ε4 carriers.
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2006 (English)In: NeuroReport, no 17, 1683-1686 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

Apolipoprotein E-epsilon 4 is the main known genetic risk factor for Alzheimer’s disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer’s disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at- risk persons. We studied nondemented apolipo-protein E-epsilon 4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon 4 carriers, and hence likely progression to Alzheimer’s disease.

Place, publisher, year, edition, pages
2006. no 17, 1683-1686 p.
Keyword [en]
genetics, fMRI, memory
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URN: urn:nbn:se:su:diva-19434OAI: diva2:185958
Available from: 2007-11-09 Created: 2007-11-09 Last updated: 2011-01-11Bibliographically approved

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Nilsson, Lars-Göran
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Department of Psychology

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