Reduced hippocampal volume in non-demented carriers of the Apolipoprotein E ε4: Relation to chronological age and recognition memory.
2006 (English)In: Neuroscience Letters, ISSN 0304-3940, Vol. 396, no 1, 23-27 p.Article in journal (Refereed) Published
Apolipoprotein E ε4 (APOE ε4) is the main known genetic risk factor for Alzheimers’ disease (AD). Some previous studies have reported structural brain changes as well as cignitive changes in non-demented APOE ε4 carriers, but the pattern of results is incosistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition-memory performance between AD-symptom free carriers (N=30) and non-carriers (N=30) of the APOE ε4 (age range: 49-79 years). We observed reduced right hippocampal volume in APOE ε4 carriers, and found that the difference was most pronounced before the age of 65 years. Further, the results revealed that APOE ε4 carriers made significantly more false alarms in the recognition-memory test, and that the number of false alarms correlated significantly with right hippocampus volume. These results indicate that younger individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. An important question for the future is whether smaller hippocampal volume represents early AD-pathology or a pre-existing trait.
Place, publisher, year, edition, pages
2006. Vol. 396, no 1, 23-27 p.
Alzheimer’s, APOE, MRI, memory, hippocampus
IdentifiersURN: urn:nbn:se:su:diva-19435DOI: doi:10.1016/j.neulet.2005.11.070OAI: oai:DiVA.org:su-19435DiVA: diva2:185959