Memory processes, aging, cognitive decline and neurodegenerative diseases.
2006 (English)In: European Psychologist, ISSN 1016-9040, Vol. 11, no 4, 304-311 p.Article in journal (Refereed) Published
This paper presents four domains of markers that have been found to predict later cognitive impairment and neurodegenerative disease. These four domains are (a) data patterns of memory performance, (b) cardiovascular factors, (c) genetic markers, and (d) brain activity. The critical features of each domain are illustrated with data from the longitudinal Betula Study on memory, aging, and health (Nilsson et al., 1997; Nilsson et al., 2004). Up to now, early signs regarding these domains have been examined one by one and it has been found that they are associated with later cognitive impairment and neurodegenerative disease. However, it was also found that each marker accounts for only a very small part of the total variance, implying that single markers should not be used as predictors for cognitive decline or neurodegenerative disease. It is discussed whether modeling and simulations should be used as tools to combine markers at different levels to increase the amount of explained variance.
Place, publisher, year, edition, pages
2006. Vol. 11, no 4, 304-311 p.
memory, aging, cognition, genetics, cardiovascular factors, brain activity
IdentifiersURN: urn:nbn:se:su:diva-19450DOI: doi:10.1027/1016-9040.11.4.304OAI: oai:DiVA.org:su-19450DiVA: diva2:185974
The Betula Study is funded by the Bank of Sweden Tercentenary Foundation (1988-0082:17; J2001-0682), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988-2000), the Swedish Council for Social Research (1988-1990: 88-0082, and 311/1991-2000), and the Swedish Research Council (345-2003-3883, 315-2004-6977).2007-11-092007-11-092011-01-11Bibliographically approved