The influence of APOE status on episodic and semantic memory: Data from a population-based study.
2006 (English)In: Neuropsychology, ISSN 0894-4105, Vol. 20, no 6, 645-657 p.Article in journal (Refereed) Published
We examined the effect of the ε4 allele of ApolipoproteinE (APOE) in non-demented healthy individuals in the age range of 35-85 years of age. In a prospective cohort study we demonstrated a more pronounced ε4-related deficit for participants in the age of 70 years and older in tasks assessing episodic recall. Somewhat smaller ε4-related deficits for these persons were found in episodic recognition. The effect of APOE on semantic memory tasks was of a different nature. Whereas APOE and age interacted for episodic memory tasks, the interaction for semantic memory tasks was between APOE and test wave. No effects of APOE were found in tasks assessing vocabulary, primary memory and priming. We also demonstrated that ε4 heterozygotes among middle-age and young-old participants performed at a higher level than non-carriers of this allele in episodic recall tasks, but not in episodic recognition tasks, nor in tasks assessing semantic memory, primary memory and priming. Furthermore, we found a dose effect, such that carriers of two ε4 alleles fail more profoundly in acquiring and recollecting episodic information than carriers of one ε4 allele, who in turn fail more than carriers of non-ε4 alleles. The pattern of findings observed for older ε4 carriers suggests that these individuals have particular difficulty when the executive task demands are high. Several factors (e.g., smaller hippocampal volumes, less effective neural repair mechanisms) may account for these findings. On the basis of the data obtained we argue that analyses of the effect of specific genes in cognition should be accompanied by assessment of performance at a specific level, with due attention to the age of the individual.
Place, publisher, year, edition, pages
2006. Vol. 20, no 6, 645-657 p.
behavioral genetics, aging, declarative memory, Apolipoprotein E, episodic memory, semantic memory, allelegenetics, memory, brain correlates
IdentifiersURN: urn:nbn:se:su:diva-19510DOI: doi:10.1037/0894-4126.96.36.1995OAI: oai:DiVA.org:su-19510DiVA: diva2:186034
The Betula Study is funded by the Bank of Sweden Tercentenary Foundation (1988-0082:17; J2001-0682), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988-2000), Swedish Council for Social Research (1988-1990: 88-0082 and 311/1991-2000), and Swedish Research Council (345-2003-3883, 315-2004-6977). Genotyping was made possible by means of the Special Research Fund of the University of Antwerp (UA-BOF) and the Fund for Scientific Research Flanders (FWO-F).2007-11-122007-11-122011-01-11Bibliographically approved