Cerebral changes on MRI and cognitive function: The CASCADE Study.
2006 (English)In: Neurobiology of Aging, ISSN 0197-4580, Vol. 27, no 1, 16-23 p.Article in journal (Refereed) Published
The aging, non-demented brain undergoes several physiological changes, some of which may and some of which may not affect cognitive function. The goal of the present study was to examine the effects of subcortical and periventricular white matter hyperintensities (WMHs), and cortical and subcortical atrophy on cognitive function (episodic and semantic memory, attention, and perceptual, cognitive, and motor speed). This was done within a European collaborative study, CASCADE (Cardiovascular Determinants of Dementia), in which Magnetic Resonance Imaging (MRI) was performed on community-dwelling individuals. The study includes 1,254 persons from eight European study centers, ranging between 64 and 76 years of age (M 69.4 + 3.3; 55% men). When demographics (age, education, and sex), study center, and concurrent brain changes had been adjusted for, periventricular WHMS predicted lower performance in motor speed and Stroop (errors). The findings are consistent with findings from lesion and functional neuroimaging studies.
Place, publisher, year, edition, pages
2006. Vol. 27, no 1, 16-23 p.
cerebral changes, white matter hyperintensities, MRI, cognition
IdentifiersURN: urn:nbn:se:su:diva-19940DOI: doi:10.1016/j.neurobiolaging.2004.12.008OAI: oai:DiVA.org:su-19940DiVA: diva2:186465