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Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.
Stockholm University.
2006 (English)In: Nucleic Acids Res, ISSN 1362-4962, Vol. 34, no 6, 1685-91 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 34, no 6, 1685-91 p.
Keyword [en]
1-Naphthylamine/analogs & derivatives/pharmacology, Animals, Cell Cycle Proteins/metabolism/*physiology, Cell Line, Cell Survival, Cricetinae, DNA Repair, DNA-Activated Protein Kinase/metabolism, DNA-Binding Proteins/metabolism/*physiology, Enzyme Activation, Enzyme Inhibitors/pharmacology, Gene Deletion, Mice, Mutation, Naphthalimides, Poly(ADP-ribose) Polymerases/*antagonists & inhibitors/genetics, Protein-Serine-Threonine Kinases/metabolism/*physiology, Quinolones/pharmacology, Recombination; Genetic, Tumor Suppressor Proteins/metabolism/*physiology
Identifiers
URN: urn:nbn:se:su:diva-20250PubMedID: 16556909OAI: oai:DiVA.org:su-20250DiVA: diva2:186776
Available from: 2007-11-23 Created: 2007-11-23 Last updated: 2011-01-11Bibliographically approved

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