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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.
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2005 (English)In: Mol Cell Biol, ISSN 0270-7306, Vol. 25, no 9, 3553-62 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 25, no 9, 3553-62 p.
Keyword [en]
Caffeine/pharmacology, Cell Cycle Proteins/genetics/metabolism/*physiology, Chromosomal Proteins; Non-Histone/metabolism, DNA Damage/*physiology, DNA Replication/drug effects/*physiology, DNA; Single-Stranded/metabolism, DNA-Binding Proteins/metabolism, Histones/metabolism, Humans, Phosphorylation, Protein Kinase Inhibitors/pharmacology, Protein Kinases/genetics/*pharmacology/physiology, Protein-Serine-Threonine Kinases/drug effects/*physiology, Purines/pharmacology, RNA; Small Interfering/genetics/pharmacology, Replication Protein A, Staurosporine/*analogs & derivatives/pharmacology, Tumor Suppressor Protein p53/metabolism
Identifiers
URN: urn:nbn:se:su:diva-20258PubMedID: 15831461OAI: oai:DiVA.org:su-20258DiVA: diva2:186784
Available from: 2007-11-23 Created: 2007-11-23 Last updated: 2011-01-12Bibliographically approved

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Lundin, CeciliaJohansson, FredrikHelleday, Thomas
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Stockholm University

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