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Applications of cell-penetrating peptides in regulation of gene expression
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2007 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 35, no Pt 4, 770-774 p.Article in journal (Refereed) Published
Abstract [en]

CPPs (cell-penetrating peptides) can be defined as short peptides that are able to efficiently penetrate cellular lipid bilayers. Because of this remarkable feature, they are excellent candidates regarding alterations in gene expression. CPPs have been utilized in in vivo and in vitro experiments as delivery vectors for different bioactive cargoes. This review focuses on the experiments performed in recent years where CPPs have been used as vectors for multiple effectors of gene expression such as oligonucleotides for antisense, siRNA (small interfering RNA) and decoy dsDNA (double-stranded DNA) applications, and as transfection agents for plasmid delivery.

Place, publisher, year, edition, pages
2007. Vol. 35, no Pt 4, 770-774 p.
Keyword [en]
antisense oligonucleotide, cell-penetrating peptide (CPR), plasmid delivery, small interfering RNA (siRNA), regulation of gene expression, transactivator of transcription (Tat)
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-20672ISI: 000249053300035PubMedID: 17635145OAI: oai:DiVA.org:su-20672DiVA: diva2:187198
Available from: 2007-12-04 Created: 2007-12-04 Last updated: 2015-04-21Bibliographically approved

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