Intracerebroventricular administration of galanin or galanin receptor subtype 1 agonist M617 induces c-Fos activation in central amygdala and dorsomedial hypothalamus
2007 (English)In: Peptides, ISSN 0196-9781, E-ISSN 1873-5169, Vol. 28, no 5, 1120-1124 p.Article in journal (Refereed) Published
The neuropeptide galanin and galanin receptors are widespread throughout cortical, limbic and midbrain areas implicated in reward, learning/memory, pain, drinking and feeding. While many studies have shown that galanin produces a variety of presynaptic and postsynaptic responses, work studying the effects of galanin on neural activation is limited. The present study examined patterns of c-Fos immunoreactivity resulting from intracerebro-ventricular administration of galanin versus saline injection in awake rats. An initial comprehensive qualitative survey was conducted to identify regions of high c-Fos expression followed up with quantitative analysis. Galanin induced a significant increase in c-Fos levels relative to saline-treated controls in dorsomedial hypothalamus and in the central nucleus of the amygdala. This pattern of activation was also produced by galanin receptor type 1 agonist M617. The present findings confirm that galanin upregulates c-Fos activation in hypothalamic nuclei, and supports roles for galanin in central amygdala-mediated food intake, and Pavlovian conditioning.
Place, publisher, year, edition, pages
2007. Vol. 28, no 5, 1120-1124 p.
anxiety, feeding, neuropeptide, motivation
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-20808DOI: 10.1016/j.peptides.2007.01.015ISI: 000246934900021PubMedID: 17337094OAI: oai:DiVA.org:su-20808DiVA: diva2:187334