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Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2007 (English)In: Molecular Biology Reports, ISSN 0301-4851, E-ISSN 1573-4978, Vol. 34, no 1, 53-60 p.Article in journal (Refereed) Published
Abstract [en]

We have demonstrated the ability of peptides derived from the third intracellular loop of GLP-1 receptor to differently modulate activity of four different types of G-proteins overexpressed in sf9 cells. In this respect, the involvement of Cys341 in inhibition of Gs and Cys341 in activation of Gs and in inhibition of Gi1, Go, and G11, respectively, indicates their potential role in discrimination between different types of G-proteins. Moreover, these two amino acids from the third intracellular loop might represent an important novel targets for covalent modification by downstream regulators in signaling through GLP-1 receptor.

Place, publisher, year, edition, pages
2007. Vol. 34, no 1, 53-60 p.
Keyword [en]
G-protein-coupled receptors, GLP-1, glucagon-like peptide-1 receptor, G proteins, immunoblotting, Sf9 cells
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-20852DOI: 10.1007/s11033-006-9015-9ISI: 000244068100008PubMedID: 17103235OAI: oai:DiVA.org:su-20852DiVA: diva2:187378
Available from: 2008-11-19 Created: 2008-11-19 Last updated: 2017-12-13Bibliographically approved

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