ApoE and vascular health synergy effects on cognitive functioning.
2006 (English)In: The 11th Cognitive Aging Conference: Atlanta, GA, USA., 2006Conference paper (Other (popular science, discussion, etc.))
The APOE gene is a determinant for the body’s transportation of cholesterol. APOE status, involving any combination of allele ε4, is also a known risk factor for developing vascular disorders and, although disputed, has a minor impact on cognitive functioning. Recent research have found that APOE ε4 status might also act as a vulnerability factor, and that the combination of APOE ε4 and certain diseases can cause a larger than expected impairment in cognitive functioning. Further, the impact of vascular health on cognitive functioning is well documented, and a main mechanism for this is variation in levels of cholesterol. The present study, which is based on data from the Betula project, examines how the interaction of APOE and vascular health (levels of cholesterol, triglycerides and blood pressure) influences performance on memory, verbal and visuospatial tasks. The results are also discussed in the perspective of age and gender differences in cognitive functioning.
Place, publisher, year, edition, pages
APOE, vascular health, cognition
IdentifiersURN: urn:nbn:se:su:diva-21383OAI: oai:DiVA.org:su-21383DiVA: diva2:187910