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Cleavage of a tail-anchored protein by signal peptidase
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Texas A&M University System Health Science Center, Texas.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2002 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 516, no 1-3, 106-108 p.Article in journal (Refereed) Published
Abstract [en]

Tail-anchored proteins are post-translationally targeted and inserted into the endoplasmic reticulum membrane. They do not use the co-translational sign at-recognition particle (SRP)-dependent pathway, but rather utilize an ill-defined, ATP-dependent mechanism. Here, we show that a tail-anchored protein can be cleaved by signal peptidase and that the sequence requirements for efficient cleavage seem to be the same as for cleavage of co-translationally targeted SRP-dependent proteins.

Place, publisher, year, edition, pages
2002. Vol. 516, no 1-3, 106-108 p.
Keyword [en]
membrane protein, signal peptide, signal peptidase, tail-anchor
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-21423DOI: 10.1016/S0014-5793(02)02511-5ISI: 000175178000022PubMedID: 11959113OAI: oai:DiVA.org:su-21423DiVA: diva2:187950
Available from: 2007-12-10 Created: 2007-12-10 Last updated: 2016-02-24Bibliographically approved

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