Cleavage of a tail-anchored protein by signal peptidase
2002 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 516, no 1-3, 106-108 p.Article in journal (Refereed) Published
Tail-anchored proteins are post-translationally targeted and inserted into the endoplasmic reticulum membrane. They do not use the co-translational sign at-recognition particle (SRP)-dependent pathway, but rather utilize an ill-defined, ATP-dependent mechanism. Here, we show that a tail-anchored protein can be cleaved by signal peptidase and that the sequence requirements for efficient cleavage seem to be the same as for cleavage of co-translationally targeted SRP-dependent proteins.
Place, publisher, year, edition, pages
2002. Vol. 516, no 1-3, 106-108 p.
membrane protein, signal peptide, signal peptidase, tail-anchor
IdentifiersURN: urn:nbn:se:su:diva-21423DOI: 10.1016/S0014-5793(02)02511-5ISI: 000175178000022PubMedID: 11959113OAI: oai:DiVA.org:su-21423DiVA: diva2:187950