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Secondary doses to patient in light ion therapy – Monte Carlo studies coupled with anthropomorphical phantoms
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
2007 (English)In: The 11th Workshop of Ion Beams in Biology and Medicine, 25-29 September 2007, Heidelberg, Germany, ISSN 1013-4506, p. 39 (2007), 2007Conference paper (Other (popular science, discussion, etc.))
Abstract [en]

Secondary particles like neutrons, protons and heavier ions produced in light ion therapeutic beams contribute to the dose delivered to tumor and healthy tissues outside the treated volume. These particles are characterized by a wide range of LET (Linear Energy Transfer) and are a source of undesirable dose to critical organs of the patient. Production of neutrons and secondary protons in therapeutic ion beams requires special concern since they possess high energies and are easily transported long distances through the patient and can generate damage in healthy tissues. As a consequence, this damage can result in the occurrence of secondary tumors. These issues are especially critical for paediatric patients since their tissues are still in rapid development and a curative treatment may result in very long survival times.

Due to the very complex interaction pathways of high energy and heavy charged ions transported in the patient, 3-D Monte Carlo (MC) particle transport codes provide a unique and very useful tool in the prediction of the physical radiation doses to organs.

In this work calculations of absorbed dose delivered to the treatment volume and to the patient’s organs exposed only to secondary particles, produced in proton and heavier ion beams, were performed with the MC code SHIELD-HIT. SHIELD-HIT simulates the interactions of hadrons and atomic nuclei of arbitrary mass number (Z, A) with complex extended targets. The simplified mathematical anthropomorphical phantoms EVA (female), ADAM (male) and a child phantom, based on the MIRD geometry, were applied in the SHIELD-HIT calculations. Calculations were also performed for homogeneous water cylindrical phantom. The incident ion beam was simulated as a quasi-monoenergetic beam with an energy spread and a Gaussian spatial distribution. The studies were also performed for parallel monoenergetic beams and for a more clinically relevant case with a spread out Bragg peak (SOBP).

Place, publisher, year, edition, pages
URN: urn:nbn:se:su:diva-21542OAI: diva2:188069
Available from: 2007-12-12 Created: 2007-12-12Bibliographically approved

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