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Survey of estrogenic and androgenic disruption in Swedish coastal waters by the analysis of bile fluid from perch and biomarkers in the three-spined stickleback
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
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Manuscript (Other academic)
URN: urn:nbn:se:su:diva-23050OAI: diva2:189979
Part of urn:nbn:se:su:diva-1373Available from: 2006-11-23 Created: 2006-11-23 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Endocrine disrupting compounds in effluent waters: Chemical analysis to evaluate exposure of fish
Open this publication in new window or tab >>Endocrine disrupting compounds in effluent waters: Chemical analysis to evaluate exposure of fish
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this thesis was to investigate if endocrine disruption related to the release of estrogenic and/or androgenic substances via sewage treatment plant and pulp mill effluents is significant in Swedish waters. Chemical analysis of bile fluid in combination with measurement of biomarkers was used for the evaluation of internal exposure and effects in fish.

Exposure to estrogenic substances was demonstrated by pronounced induction of the yolk protein precursor vitellogenin in fish exposed in cages downstream of a small domestic Swedish sewage treatment plant. Estrogenic substances identified in bile from the fish included the natural estrogens, the synthetic estrogen ethinylestradiol and some estrogenic phenols. The bile levels of estrogenic substances corresponded well with the plasma levels of vitellogenin. Significant concentrations of the estrogenic substances were also determined in the effluent water, and it was suggested that the level of ethinylestradiol was sufficient to explain a major part of the observed estrogenicity. Low or no induction of vitellogenin was observed in fish when exposed to final effluent from two modern Swedish sewage treatment plants, and it was concluded that a well functioning biological treatment reduces the amounts of estrogenic substances from the sewage water and that slow sand filtration contributes to further reduction. A field survey along the Baltic Sea coast revealed no signs of estrogenic or androgenic disruption in recipients of sewage treatment plants or pulp mills. This is likely due to efficient water treatment and high dilution rates in the recipients. Endocrine disruption might still be of local concern in receiving waters of less treated effluents that have low dilution rates.

A sensitive method for determination of estrogenic substances in water was developed, which will make it possible to establish bioconcentration relationships between water and fish, and dose-response relationships with biomarkers in fish.

Place, publisher, year, edition, pages
Stockholm: Institutionen för tillämpad miljövetenskap (ITM), 2006. 56 p.
National Category
Chemical Sciences
urn:nbn:se:su:diva-1373 (URN)91-7155-324-X (ISBN)
Public defence
2006-12-15, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 8 C, Stockholm, 10:00
Available from: 2006-11-23 Created: 2006-11-23 Last updated: 2013-12-10Bibliographically approved

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