Expression and evolution of the Drosophila attacin/diptericin gene family
2000 (English)In: Biochemical and Biophysical Research Communications, ISSN 0006-291X, Vol. 279, no 2, 574-81 p.Article in journal (Refereed) Published
We describe the genes for three new glycine-rich antimicrobial peptides in (support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. Drosophila, two attacinsAttC and AttD) and one diptericin (DptB). Their structuresAttC is similar to the nearby AttA on a different chromosome. Intriguingly, and AttB genes. AttD is more divergent and locatedAttD may encode an intracellular attacin tandem to the closely related DptB is linked inDiptericin. However, the DptB and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in and unexpectedly also in gene product contains a furin-like cleavage siteimd mutants,Tl2 mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling.
Place, publisher, year, edition, pages
Elsevier , 2000. Vol. 279, no 2, 574-81 p.
Research subject Cellbiology
IdentifiersURN: urn:nbn:se:su:diva-23157DOI: 10.1006/bbrc.2000.3988OAI: oai:DiVA.org:su-23157DiVA: diva2:190442
Part of urn:nbn:se:su:diva-1702004-05-132004-05-132009-12-22Bibliographically approved