2-Pyridylphosphonates: A New type of Modification for Nucleotide Analogues
2001 (English)In: Tetrahedron Letters, ISSN 0040-4039, Vol. 42, no 11, 2217-2220 p.Article in journal (Refereed) Published
Suitably protected dithymidine H-phosphonates afforded the corresponding dinucleoside 2-pyridylphosphonates upon treatment with N-methoxypyridinium tosylate in acetonitrile in the presence of 1,8-diazabicylo[5.4.0]undec-7-ene (DBU). The reaction was rapid (ca. 5 min), practically quantitative and proceeded stereospecifically, most likely with retention of configuration at the phosphorus centre.
A simple and efficient protocol for the preparation of a new type of oligonucleotide analogue bearing a 2-pyridylphosphonate internucleotide linkage was developed
Place, publisher, year, edition, pages
Elsevier , 2001. Vol. 42, no 11, 2217-2220 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-23235DOI: 10.1016/S0040-4039(01)00115-0OAI: oai:DiVA.org:su-23235DiVA: diva2:190870
Part of urn:nbn:se:su:diva-2022004-08-192004-08-192010-01-05Bibliographically approved