Enantioselective addition of aldehydes to amines via combined catalytic biomimetic oxidation and organocatalytic C-C- bond formation
2005 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 46, no 23, 3965-3968 p.Article in journal (Refereed) Published
The biomimetic catalytic enantioselective addition of aldehydes to amines is reported. This was accomplished by combining biomimetic coupled catalytic aerobic oxidation of amines involving ruthenium-induced dehydrogenation and organocatalytic asymmetric Mannich reactions. The novel one-pot reactions furnished β-amino aldehyde and α-amino acid derivatives in high yields with excellent chemoselectivity and up to >99% ee.
Place, publisher, year, edition, pages
Elsevier ltd , 2005. Vol. 46, no 23, 3965-3968 p.
Biomimetic oxidation; Catalysis; Asymmetric synthesis; Ruthenium; Proline
IdentifiersURN: urn:nbn:se:su:diva-23691DOI: 10.1016/j.tetlet.2005.04.047OAI: oai:DiVA.org:su-23691DiVA: diva2:193996
Part of urn:nbn:se:su:diva-4472005-04-072005-04-072010-09-21Bibliographically approved