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Norepinephrine Stimulated Glucose Uptake in Brown Adipocytes is Augmented through an Increase in GLUT1 Gene Expression and Protein at the Plasma Membrane
Stockholm University, Faculty of Science, Wenner-Gren Institute for Experimental Biology.
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Manuscript (Other academic)
URN: urn:nbn:se:su:diva-23921OAI: diva2:195341
Part of urn:nbn:se:su:diva-549Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Adrenergic stimulation of glucose uptake in brown adipocytes
Open this publication in new window or tab >>Adrenergic stimulation of glucose uptake in brown adipocytes
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this study was to investigate adrenergically stimulated glucose uptake in brown adipose tissue (BAT) with the focus on receptor subtypes and intracellular signalling pathways. As a model system, we used primary cultured brown adipocytes.

Adrenergic stimulation of glucose uptake occurs via β3-AR in wild type cells and β1-/α1-ARs in β3-KO cells, includes activation of adenylyl cyclase and cAMP formation, activation of PKA, PI3K, PKC and AMPK (Paper I, II, III). Interestingly, UCP1 activity is not required for the AMPK function in brown adipocytes (Paper III). Long-term adrenergic stimulation of glucose uptake induces an increase in GLUT1 mRNA and protein levels stimulating GLUT1 translocation to the plasma membrane (Paper IV).

Place, publisher, year, edition, pages
Stockholm: Wenner-Grens institut för experimentell biologi, 2005. 129 p.
National Category
urn:nbn:se:su:diva-549 (URN)91-7155-096-8 (ISBN)
Public defence
2005-06-16, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 8 C, Stockholm, 10:00
Available from: 2005-05-26 Created: 2005-05-26Bibliographically approved

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