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Adrenergic stimulation of glucose uptake in brown adipocytes
Stockholm University, Faculty of Science, Wenner-Gren Institute for Experimental Biology.
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The aim of this study was to investigate adrenergically stimulated glucose uptake in brown adipose tissue (BAT) with the focus on receptor subtypes and intracellular signalling pathways. As a model system, we used primary cultured brown adipocytes.

Adrenergic stimulation of glucose uptake occurs via β3-AR in wild type cells and β1-/α1-ARs in β3-KO cells, includes activation of adenylyl cyclase and cAMP formation, activation of PKA, PI3K, PKC and AMPK (Paper I, II, III). Interestingly, UCP1 activity is not required for the AMPK function in brown adipocytes (Paper III). Long-term adrenergic stimulation of glucose uptake induces an increase in GLUT1 mRNA and protein levels stimulating GLUT1 translocation to the plasma membrane (Paper IV).

Place, publisher, year, edition, pages
Stockholm: Wenner-Grens institut för experimentell biologi , 2005. , 129 p.
National Category
Physiology
Identifiers
URN: urn:nbn:se:su:diva-549ISBN: 91-7155-096-8 (print)OAI: oai:DiVA.org:su-549DiVA: diva2:195342
Public defence
2005-06-16, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 8 C, Stockholm, 10:00
Opponent
Supervisors
Available from: 2005-05-26 Created: 2005-05-26Bibliographically approved
List of papers
1. Norepinephrine increases glucose transport in brown adipocytes via {beta3}-adrenoceptors through a cAMP, PKA, and PI3-kinasedependent pathway stimulating conventional and novel PKCs
Open this publication in new window or tab >>Norepinephrine increases glucose transport in brown adipocytes via {beta3}-adrenoceptors through a cAMP, PKA, and PI3-kinasedependent pathway stimulating conventional and novel PKCs
2004 In: Endocrinology, ISSN 0013-7227, Vol. 145, no 1, 269-280 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:su:diva-23918 (URN)
Note
Part of urn:nbn:se:su:diva-549Available from: 2005-05-26 Created: 2005-05-26Bibliographically approved
2. {alpha}1- and {beta}1-Adrenoceptor Signaling Fully Compensates for {beta}3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake
Open this publication in new window or tab >>{alpha}1- and {beta}1-Adrenoceptor Signaling Fully Compensates for {beta}3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake
2005 In: Endocrinology, ISSN 0013-7227, Vol. 146, no 5, 2271-2284 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:su:diva-23919 (URN)
Note
Part of urn:nbn:se:su:diva-549Available from: 2005-05-26 Created: 2005-05-26Bibliographically approved
3. {beta}-Adrenoreceptors, but not {alpha}- Adrenoreceptors, Stimulate AMPK in Brown Adipocytes Independently of UCP1
Open this publication in new window or tab >>{beta}-Adrenoreceptors, but not {alpha}- Adrenoreceptors, Stimulate AMPK in Brown Adipocytes Independently of UCP1
In: DiabetologiaArticle in journal (Refereed) Submitted
Identifiers
urn:nbn:se:su:diva-23920 (URN)
Note
Part of urn:nbn:se:su:diva-549Available from: 2005-05-26 Created: 2005-05-26Bibliographically approved
4. Norepinephrine Stimulated Glucose Uptake in Brown Adipocytes is Augmented through an Increase in GLUT1 Gene Expression and Protein at the Plasma Membrane
Open this publication in new window or tab >>Norepinephrine Stimulated Glucose Uptake in Brown Adipocytes is Augmented through an Increase in GLUT1 Gene Expression and Protein at the Plasma Membrane
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Manuscript (Other academic)
Identifiers
urn:nbn:se:su:diva-23921 (URN)
Note
Part of urn:nbn:se:su:diva-549Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2010-01-13Bibliographically approved

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