Chemoenzymatic Dynamic Kinetic Resolution of Allylic Alcohols: A Highly Enantioselective Route to Acyloin Acetates
2007 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 9, no 17, 3401-3404 p.Article in journal (Refereed) Published
Dynamic kinetic resolution (DKR) of a series of sterically hindered allylic alcohols has been conducted with Candida antarctica lipase B (CALB) and ruthenium catalyst 1. The optically pure allylic acetates obtained were subjected to oxidative cleavage to give the corresponding acylated acyloins in high yields without loss of chiral information.
Place, publisher, year, edition, pages
2007. Vol. 9, no 17, 3401-3404 p.
IdentifiersURN: urn:nbn:se:su:diva-24335DOI: 10.1021/ol071395vISI: 000248658800052OAI: oai:DiVA.org:su-24335DiVA: diva2:197250