High-yielding metalloenzymatic dynamic kinetic resolution of fluorinated aryl alcohols
2007 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 48, no 31, 5471-5474 p.Article in journal (Refereed) Published
Dynamic kinetic resolution (DKR) of various fluorinated aryl alcohols by a combination of lipase-catalyzed enzymatic resolution with in situ ruthenium-catalyzed alcohol racemization is described. (R)-Selective Candida antarctica lipase B (CALB) was employed for transesterification of different fluoroaryl alcohols in DKR reactions delivering the corresponding acetates in high yield (97%) with excellent enantiomeric excess (98%).
Place, publisher, year, edition, pages
2007. Vol. 48, no 31, 5471-5474 p.
IdentifiersURN: urn:nbn:se:su:diva-24336DOI: 10.1016/j.tetlet.2007.05.175ISI: 000248527400026OAI: oai:DiVA.org:su-24336DiVA: diva2:197251