Preparation of nucleoside H-phosphonoselenoate monoesters via the phosphinate approach
2005 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 24, no 10-12, 1627-1633 p.Article in journal (Refereed) Published
An efficient entry to nucleoside 3'-H-phosphonoselenoate monoesters via phosphinate intermediates was developed. It involves a reaction of suitably protected nucleosides with triethylammonium phosphinate in the presence of pivaloyl chloride, followed by selenization of the intermediate nucleoside phosphinates with triphenylphosphine selenide, to produce the corresponding nucleoside H-phosphonoselenoates in 86-92% yields.
Place, publisher, year, edition, pages
Taylor & Francis , 2005. Vol. 24, no 10-12, 1627-1633 p.
H-Phosphonoselenoate monoesters; H-Phosphinates; H-Phosphonate approach; Triphenylphosphine selenide; Triphenyl phosphoroselenoate
IdentifiersURN: urn:nbn:se:su:diva-24689DOI: 10.1080/15257770500266883OAI: oai:DiVA.org:su-24689DiVA: diva2:198115
Part of urn:nbn:se:su:diva-7362005-11-112005-11-112010-12-08Bibliographically approved