FcγRIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD)
Stockholm University, Faculty of Science, Wenner-Gren Institute for Experimental Biology2007 (English)In: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, Vol. 77, no 6, 1074-1078 p.Article in journal (Refereed) Published
The pathologic manifestations of Onchocerca volvulus infection depend on the interplay between the host and the parasite. A genetic single nucleotide polymorphism in the FcγRIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis. This study investigated the relationship between this polymorphism and disease outcome. FcγRIIa genotyping was performed on clinically characterized onchocerciasis patients (N = 100) and healthy controls (N = 74). FcγRIIa genotype R/R131 frequencies were significantly higher among patients with severe dermatopathology (P < 0.001). Increased risk of developing this form was mostly associated with one tribe (Masalit) (OR = 3.2, 95% CI 1-9.9, P = 0.042). The H131 allele was found to be significantly associated with a reduced risk of having the severe form of the disease (adjusted OR = 0.26, 95% CI = 0.13-0.46, P < 0.001). Our findings suggest that the polymorphism influences the clinical outcome of onchocerciasis.
Place, publisher, year, edition, pages
2007. Vol. 77, no 6, 1074-1078 p.
Eye disease ; Africa ; Infection ; Parasitosis ; Helminthiasis ; Nematode disease ; Filariosis ; Sudan ; Tropical medicine ; Human ; Severe ; Disease development ; Polymorphism ; Skin disease ; Onchocerciasis ;
Microbiology in the medical area
IdentifiersURN: urn:nbn:se:su:diva-25278ISI: 000252123200016OAI: oai:DiVA.org:su-25278DiVA: diva2:199306
Part of urn:nbn:se:su:diva-7932006-01-122006-01-122010-08-09Bibliographically approved