Neurocognitive deficits are considered a core feature of schizophrenia.
Deficits covering a wide range of functions have been well
documented. However there are still relatively few longitudinal
studies regarding the long-term development of neurocognitive
impairment. The current study examined the effect of time in
schizophrenic patients and controls concerning cognitive functions. A
neurocognitive test-battery was administered on two occasions to 36
schizophrenic patients and 46 healthy controls with approximately 4.5
year interval. Results showed that schizophrenic patients performed
significantly worse on all measures on both occasions. No significant
decline was found over time for either group except for on Trail
Making Test, part B. Improvement on Continuous Performance Test
was found for affected patients and improvement on Rey Auditory
Verbal Learning Test was found for controls. Age was related to
outcome in controls and education was related to outcome in patients.
The conclusion is drawn that neurocognitive measures are relatively
stable over 4.5 years in patients with schizophrenia, in line with earlier
research. The authors discuss the impact of age and education and
limitations of the study.
2008. , 36 p.