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Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch Cohort
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
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2004 In: Environmental Health Perspectives, ISSN 0091-6765, Vol. 112, no 11, 1208-1212 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2004. Vol. 112, no 11, 1208-1212 p.
Identifiers
URN: urn:nbn:se:su:diva-25331OAI: oai:DiVA.org:su-25331DiVA: diva2:199490
Note
Part of urn:nbn:se:su:diva-805Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
In thesis
1. Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification
Open this publication in new window or tab >>Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

PCBs are well known environmental pollutants. They are also precursors to metabolites, as the hydroxy-PCBs and the methylsulfonyl-PCBs. This thesis presents a validated methodology for analysis of PCB metabolites and a structural identification of 38 hydroxy-PCBs in human blood. Further methodological development resulted in an identification of a similar number of methylsulfonyl-PCBs.

The analytical method has been applied in two extensive studies of humans, consisting of maternal and cord blood from Dutch women and of blood from humans living in Slovakia. The Dutch shows that the relative transfer of hydroxy-PCBs from the mother to the foetus is higher compared to the PCBs. Even though the chemical plant in Michalovce in Slovakia had been shut down for over 20 years, the concentrations of PCB and its metabolites were among the highest detected in European human blood.

Place, publisher, year, edition, pages
Stockholm: Institutionen för miljökemi, 2006. 54 p.
Keyword
PCB, polychlorinated biphenyls, metabolites, human blood
National Category
Environmental Sciences
Identifiers
urn:nbn:se:su:diva-805 (URN)91-7155-167-0 (ISBN)
Public defence
2006-02-10, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 12 A, Stockholm, 13:00
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Supervisors
Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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  • de-DE
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  • en-US
  • fi-FI
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  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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