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Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
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2006 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 40, no 12, 3696-3703 p.Article in journal (Refereed) Published
Abstract [en]

The over-riding aim of the present investigation was to obtain information concerning exposure that can be used as a basis for studies on the health of individuals residing in the Michalovce area of eastern Slovakia which is heavily contaminated by polychlorinated biphenyls (PCBs). Accordingly, this work focused on determination of serum concentrations of hydroxylated (OH-PCBs) and methylsulfonyl-substituted (MeSO2-PCBs) metabolites of PCBs. One hundred and twenty-two men and women, 20-59 years of age, living in the contaminated area and 175 from the control Stropkov/Svidnik district were selected randomly from 2047 sampled individuals. Following a specially designed cleanup, the levels of various congeners of OH-PCBs and MeSO2-PCBs in their serum were quantitated by gas chromatography and mass spectrometry, with comparison to authentic reference standards. The median concentrations of PCB congeners and their OH-PCB and MeSO2-PCB metabolites were 2-3-fold higher in residents of Michalovce than in the control region. The levels of certain OH-PCB metabolites were in the same high range as those of individual PCB congeners, whereas the MeSO2-PCB levels were significantly lower. The PCB and their metabolites were present at slightly higher concentrations in men than in women, and the serum levels of PCBs and MeSO2-PCBs increased with increasing age. Thus, the environmental contamination resulting from previous industrial production of PCBs has led to elevated concentrations of PCBs and their metabolites in the serum of individuals living in the Michalovce area.

Place, publisher, year, edition, pages
2006. Vol. 40, no 12, 3696-3703 p.
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-25332DOI: 10.1021/es0525657PubMedID: 16830529OAI: oai:DiVA.org:su-25332DiVA: diva2:199491
Available from: 2006-01-18 Created: 2006-01-18 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification
Open this publication in new window or tab >>Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

PCBs are well known environmental pollutants. They are also precursors to metabolites, as the hydroxy-PCBs and the methylsulfonyl-PCBs. This thesis presents a validated methodology for analysis of PCB metabolites and a structural identification of 38 hydroxy-PCBs in human blood. Further methodological development resulted in an identification of a similar number of methylsulfonyl-PCBs.

The analytical method has been applied in two extensive studies of humans, consisting of maternal and cord blood from Dutch women and of blood from humans living in Slovakia. The Dutch shows that the relative transfer of hydroxy-PCBs from the mother to the foetus is higher compared to the PCBs. Even though the chemical plant in Michalovce in Slovakia had been shut down for over 20 years, the concentrations of PCB and its metabolites were among the highest detected in European human blood.

Place, publisher, year, edition, pages
Stockholm: Institutionen för miljökemi, 2006. 54 p.
Keyword
PCB, polychlorinated biphenyls, metabolites, human blood
National Category
Environmental Sciences
Identifiers
urn:nbn:se:su:diva-805 (URN)91-7155-167-0 (ISBN)
Public defence
2006-02-10, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 12 A, Stockholm, 13:00
Opponent
Supervisors
Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
2. Assessment of Environmental Pollutants in Humans from Four Continents: Exposure levels in Slovakia, Guinea-Bissau, Nicaragua and Bangladesh
Open this publication in new window or tab >>Assessment of Environmental Pollutants in Humans from Four Continents: Exposure levels in Slovakia, Guinea-Bissau, Nicaragua and Bangladesh
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Humans are continuously exposed to complex mixtures of anthropogenic chemicals. This thesis focus on human exposure to persistent organic pollutants (POPs). POPs ability to bioaccumulate and biomagnify together with the extensive historical use of POPs in e.g. agriculture and industry have resulted in detection of these compounds in humans and animals from all over the world. Adverse health effects caused by POPs are of particular concern for newborns and young individuals.

The objective of this thesis is to assess human exposure to a selected set of POPs and their metabolites. More specifically, one aim of my thesis is to determine the exposure to polychlorinated biphenyls (PCBs) and in particular their methylsulfonyl and hydroxylated metabolites in humans from a “hot-spot” area of PCB contamination in eastern Slovakia. The maternal transfer of these chemicals is studied. Further, another specific aim is to determine occurrence, levels and, when possible, temporal trends of POPs in children and adults from three developing countries, Nicaragua, Guinea-Bissau and Bangladesh.

High concentrations of PCBs and their metabolites are shown in men and women from Michalovce in eastern Slovakia. Placental transfer of methylsulfonyl-metabolites of PCBs and 4,4’-DDE was observed for the first time. Decreasing temporal trends of the majority of POPs are shown in serum from a cohort of policemen from Guinea-Bissau. In contrast, the levels of polybrominated diphenyl ethers (PBDEs) show an increasing time trend. Within five years, decreasing levels of POPs were also shown in children working and living at a waste disposal site in Nicaragua. Children working and living at waste disposal sites in Bangladesh have considerably lower levels of POPs compared to the children from Nicaragua except for 4,4’-DDT and 4,4’-DDE that are present at very high concentrations, indicating ongoing use of technical DDT.

There are many studies on levels and trends of environmental pollutants from the developed industrial countries in the world, whereas data from developing countries is still scarce. This thesis contributes to partly fill this data gap since it includes assessments of POPs in children and adults from four countries on four continents.

Place, publisher, year, edition, pages
Stockholm: Department of Materials and Environmental Chemistry (MMK), Stockholm University, 2010. 68 p.
Keyword
POPs, PCB, DDT, PBDE, HCH, metabolites, human exposure, children's exposure, placental transfer
National Category
Environmental Sciences
Research subject
Environmental Chemistry
Identifiers
urn:nbn:se:su:diva-43807 (URN)978-91-7447-136-6 (ISBN)
Public defence
2010-12-03, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 16 B, Stockholm, 13:00 (English)
Opponent
Supervisors
Note
At the time of doctoral defense, the following papers were unpublished and had a status as follows: Paper 5: Manuscript. Paper 6: Manuscript.Available from: 2010-11-11 Created: 2010-10-28 Last updated: 2012-01-18Bibliographically approved

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Linderholm, LindaAthanasiadou, MariaAthanassiadis, IoannisBignert, AndersBergman, Åke
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