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Polychlorinated biphenyls and their metabolites in human blood: Method development, identification and quantification
Stockholm University, Faculty of Science, Department of Environmental Chemistry.
Responsible organisation
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

PCBs are well known environmental pollutants. They are also precursors to metabolites, as the hydroxy-PCBs and the methylsulfonyl-PCBs. This thesis presents a validated methodology for analysis of PCB metabolites and a structural identification of 38 hydroxy-PCBs in human blood. Further methodological development resulted in an identification of a similar number of methylsulfonyl-PCBs.

The analytical method has been applied in two extensive studies of humans, consisting of maternal and cord blood from Dutch women and of blood from humans living in Slovakia. The Dutch shows that the relative transfer of hydroxy-PCBs from the mother to the foetus is higher compared to the PCBs. Even though the chemical plant in Michalovce in Slovakia had been shut down for over 20 years, the concentrations of PCB and its metabolites were among the highest detected in European human blood.

Place, publisher, year, edition, pages
Stockholm: Institutionen för miljökemi , 2006. , 54 p.
Keyword [en]
PCB, polychlorinated biphenyls, metabolites, human blood
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-805ISBN: 91-7155-167-0 (print)OAI: oai:DiVA.org:su-805DiVA: diva2:199492
Public defence
2006-02-10, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 12 A, Stockholm, 13:00
Opponent
Supervisors
Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
List of papers
1. Extraction and cleanup methods for analysis of phenolic and neutral organohalogens in plasma
Open this publication in new window or tab >>Extraction and cleanup methods for analysis of phenolic and neutral organohalogens in plasma
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2000 In: Journal of Analytical Toxicology, ISSN 0146-4760, Vol. 24, 996-703 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:su:diva-25329 (URN)
Note
Part of urn:nbn:se:su:diva-805Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
2. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma
Open this publication in new window or tab >>Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma
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2002 In: Archives of Environmental Contamination and Toxicology, ISSN 0090-4341, Vol. 42, 105-117 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:su:diva-25330 (URN)
Note
Part of urn:nbn:se:su:diva-805Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
3. Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch Cohort
Open this publication in new window or tab >>Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch Cohort
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2004 In: Environmental Health Perspectives, ISSN 0091-6765, Vol. 112, no 11, 1208-1212 p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:su:diva-25331 (URN)
Note
Part of urn:nbn:se:su:diva-805Available from: 2006-01-18 Created: 2006-01-18Bibliographically approved
4. Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia
Open this publication in new window or tab >>Levels of PCBs and their metabolites in the serum of residents of a highly contaminated area in eastern Slovakia
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2006 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 40, no 12, 3696-3703 p.Article in journal (Refereed) Published
Abstract [en]

The over-riding aim of the present investigation was to obtain information concerning exposure that can be used as a basis for studies on the health of individuals residing in the Michalovce area of eastern Slovakia which is heavily contaminated by polychlorinated biphenyls (PCBs). Accordingly, this work focused on determination of serum concentrations of hydroxylated (OH-PCBs) and methylsulfonyl-substituted (MeSO2-PCBs) metabolites of PCBs. One hundred and twenty-two men and women, 20-59 years of age, living in the contaminated area and 175 from the control Stropkov/Svidnik district were selected randomly from 2047 sampled individuals. Following a specially designed cleanup, the levels of various congeners of OH-PCBs and MeSO2-PCBs in their serum were quantitated by gas chromatography and mass spectrometry, with comparison to authentic reference standards. The median concentrations of PCB congeners and their OH-PCB and MeSO2-PCB metabolites were 2-3-fold higher in residents of Michalovce than in the control region. The levels of certain OH-PCB metabolites were in the same high range as those of individual PCB congeners, whereas the MeSO2-PCB levels were significantly lower. The PCB and their metabolites were present at slightly higher concentrations in men than in women, and the serum levels of PCBs and MeSO2-PCBs increased with increasing age. Thus, the environmental contamination resulting from previous industrial production of PCBs has led to elevated concentrations of PCBs and their metabolites in the serum of individuals living in the Michalovce area.

National Category
Environmental Sciences
Identifiers
urn:nbn:se:su:diva-25332 (URN)10.1021/es0525657 (DOI)16830529 (PubMedID)
Available from: 2006-01-18 Created: 2006-01-18 Last updated: 2017-12-13Bibliographically approved

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