Enantiopure 1,5-diols from dynamic kinetic asymmetric transformation: Useful synthetic intermediates for the preparation of heterocycles
Stockholm University, Faculty of Science, Department of Organic Chemistry2008 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 10, no 10, 2027-2030 p.Article in journal (Refereed) Published
Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1,5-diols has been performed in the presence of Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase H (PS-C II), and ruthenium catalyst 4. The resulting optically pure 1,5-diacetates are useful synthetic intermediates, which was demonstrated by the syntheses of both an enantiopure 2,6-disubstituted piperidine and an enantiopure 3,5-disubstituted morpholine.
Place, publisher, year, edition, pages
2008. Vol. 10, no 10, 2027-2030 p.
IdentifiersURN: urn:nbn:se:su:diva-25570DOI: 10.1021/ol800468hISI: 000255694100038OAI: oai:DiVA.org:su-25570DiVA: diva2:199993