Dynamic Kinetic Asymmetric Transformation of 1,4-diols and Preparation of Trans-2,5-Disubstituted pyrrolidines
2009 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 50, no 26, 3237-3240 p.Article in journal (Refereed) Published
Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1,4-diols is carried out with Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase II (PS-C II), and a ruthenium catalyst. A β-chloro-substituted 1,4-diol is successfully transformed into an optically pure 1,4-diacetate, which is a highly useful synthetic intermediate. The usefulness of the optically pure 1,4-diacetates is demonstrated by the synthesis of enantiopure 2,5-disubstituted pyrrolidines.
Place, publisher, year, edition, pages
2009. Vol. 50, no 26, 3237-3240 p.
IdentifiersURN: urn:nbn:se:su:diva-25588DOI: 10.1016/j.tetlet.2009.02.079ISI: 000267070700029OAI: oai:DiVA.org:su-25588DiVA: diva2:200015