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Energy-range relation and mean energy variation in therapeutic particle beams
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
2008 (English)In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 35, no 1, 159-170 p.Article in journal (Refereed) Published
Abstract [en]

Analytical expressions for the mean energy and range of therapeutic light ion beams and low- and high-energy electrons have been derived, based on the energy dependence of their respective stopping powers. The new mean energy and range relations are power-law expressions relevant for light ion radiation therapy, and are based on measured practical ranges or known tabulated stopping powers and ranges for the relevant incident particle energies. A practical extrapolated range, Rp, for light ions was defined, similar to that of electrons, which is very closely related to the extrapolated range of the primary ions. A universal energy-range relation for light ions and electrons that is valid for all material mixtures and compounds has been developed. The new relation can be expressed in terms of the range for protons and alpha particles, and is found to agree closely with experimental data in low atomic number media and when the difference in the mean ionization energy is low. The variation of the mean energy with depth and the new energy-range relation are useful for accurate stopping power and mass scattering power calculations, as well as for general particle transport and dosimetry applications.

Place, publisher, year, edition, pages
2008. Vol. 35, no 1, 159-170 p.
Keyword [en]
biological techniques, dosimetry, particle beams, radiation therapy, energy-range relations, mean energy variations, universal energy-range relation, ion practical range
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:su:diva-25651DOI: 10.1118/1.2815935ISI: 000251910300019OAI: oai:DiVA.org:su-25651DiVA: diva2:200129
Available from: 2008-11-24 Created: 2008-11-21 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Development of analytical transport methods for biologically optimized light ion therapy
Open this publication in new window or tab >>Development of analytical transport methods for biologically optimized light ion therapy
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A general objective in the treatment of cancer is to eradicate the tumour cells without inducing severe complications in healthy normal tissue. The use of light ions for radiation therapy increases the possibility to deliver tumour suicidal doses with very low probability of normal tissue injury, not least in cases where the target is unresectable, radioresistant and located to near organs at risk. The success in the application of such beams in radiation therapy is largely determined by a thorough understanding of particle transport, biological dose response relations and their accurate integration in the treatment planning system. The focus has therefore been on the radiation quality of the light ions, their transport and to develop analytical tools and theories for their application in biologicallly optimized radiation treatment planning. New radiation quality results has been presented, new analytical approaches for the light ion transport in matter have been developed and new range concepts have been defined. A refined version of the Monte Code SHIELD-HIT was developed and used for calculating fundamental physical transport quantities that could be directly compared with the analytical theories and methods as well as with experimental data. The present results could be useful for biological optimized treatment planning, biologically optimized dose delivery techniques, dosimetry and for in vivo dose delivery verification.

Place, publisher, year, edition, pages
Stockholm: Medicinsk strålningsfysik (tills m KI), 2008. 44 p.
Keyword
Radiotherapy, radiation quality, energy-range relations, light ion transport, pencil beam, Monte Carlo
National Category
Physical Sciences
Research subject
Medical Radiation Physics
Identifiers
urn:nbn:se:su:diva-8343 (URN)978-91-7155-783-4 (ISBN)
Public defence
2008-12-16, föreläsningssalen, Cancer Centrum Karolinska, R8:00, Karolinska universitetssjukhuset, Solna, 09:15
Opponent
Supervisors
Available from: 2008-11-24 Created: 2008-11-21 Last updated: 2013-01-17Bibliographically approved

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