3-(4-hydroxymethylphenylsulfanyl)propanoic acid (HMPPA) as a new safety catch linker in solid phase peptide synthesis
2006 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 32, no 7, 5829-5832 p.Article in journal (Refereed) Published
A new safety catch linker, 3-(4-hydroxymethylphenylsulfanyl)propanoic acid (HMPPA), is described for use in solid phase peptide synthesis. The linker is readily synthesized from commercially available chemicals in a more cost efficient way compared to similar reported linkers. The HMPPA linker is easily attached to an amino derivatized solid support followed by on-resin oxidation of the thioether to sulfoxide, thereby making the linker very stable towards strong acid treatment. Final resin cleavage is performed by reductive acidolysis.
Place, publisher, year, edition, pages
Elsevier Ltd , 2006. Vol. 32, no 7, 5829-5832 p.
IdentifiersURN: urn:nbn:se:su:diva-25838DOI: 10.1016/j.tetlet.2006.04.138OAI: oai:DiVA.org:su-25838DiVA: diva2:200648