Change search
ReferencesLink to record
Permanent link

Direct link
The WSTF-SNF2h assembly regulates Pol I transcription
Stockholm University, Faculty of Science, Wenner-Gren Institute for Experimental Biology.
Manuscript (Other academic)
URN: urn:nbn:se:su:diva-25925OAI: diva2:200807
Part of urn:nbn:se:su:diva-991Available from: 2006-04-27 Created: 2006-04-27 Last updated: 2010-01-13Bibliographically approved
In thesis
1. Chromatin remodelling in Pol I and III transcription
Open this publication in new window or tab >>Chromatin remodelling in Pol I and III transcription
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Compaction of chromosomes in the eukaryotic cell is due to interactions between DNA and proteins and interactions between proteins. These two types of interaction form a dynamic structure, known as "chromatin". The condensation of chromatin must be carefully regulated, since the structure is an obstacle for factors that need access to the DNA. An extensive range of components, one group of which is the ATP-dependent chromatin remodel-ling complexes, controls the accessibility of DNA. These complexes have been studied in a variety of eukaryotic systems, and their functions in major events in the cell, such as replication, DNA-repair and transcription have been established, as have their roles in the assembly and maintenance of chromatin. All of the complexes contain a highly conserved ATPase, which belongs to the SWI2/SNF2 family of proteins, one group of which is known as the ISWI proteins. There are two forms of ISWI in human, known as "SNF2h" and "SNF2l".

We have identified a human SNF2h-assembly, B-WICH, that consists of SNF2h, William’s syndrome transcription factor (WSTF), nuclear myosin (NM1), and a number of additional nuclear proteins including the Myb-binding protein 1a (Myb bp1a), SF3b155/SAP155, the RNA helicase II/Guα, the proto-oncogene Dek, and the Cockayne Syndrome protein B (CSB). The 45S rRNA, 5S rRNA and 7SL RNA are all parts of the B-WICH assembly. The formation of B-WICH depends on active transcription, and is implicated in the regulation of both RNA transcription by both pol I and pol III. The B-WICH provides a link between RNA and the chromatin structure.

Place, publisher, year, edition, pages
Stockholm: Wenner-Grens institut för experimentell biologi, 2006. 66 p.
National Category
Cell Biology
urn:nbn:se:su:diva-991 (URN)91-7155-229-4 (ISBN)
Public defence
2006-05-18, Ahlmansalen, Geovetenskapens hus, Svante Arrhenius väg 8, Stockholm, 10:00
Available from: 2006-04-27 Created: 2006-04-27Bibliographically approved

Open Access in DiVA

No full text

By organisation
Wenner-Gren Institute for Experimental Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link