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Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata)
Stockholm University, Faculty of Science, Department of Zoology. (HOL)
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM). (Lennart Balk)
Södertörns högskola. (HOL)
2006 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, Vol. 147, no 3, 323-328 p.Article in journal (Refereed) Published
Abstract [en]

In mammalian and avian vertebrate groups, androgens act as controlling agents on male aggression and courtship behaviour by their conversion to oestrogens by cytochrome P450 aromatase in well-defined brain regions. Despite the fact that bony fishes have exceptionally high brain aromatase activity, little is known about it’s possible regulatory effects on the reproductive behaviours of teleosts. In this study, Endler guppy males (Poecilia reticulata) were subjected to 26–29 days of 24-h exposure to two different concentrations (15 and 100 μg/L) of the aromatase inhibitor fadrozole in the water. Compared with the control males, two of three courtship activities in males exposed to the higher concentration were reduced when they were paired with receptive stimulus females. Reduction in brain aromatase activity was confirmed in both exposed groups with the use of the tritiated water assay.

Place, publisher, year, edition, pages
Amsterdam, The Netherlands: Elsevier , 2006. Vol. 147, no 3, 323-328 p.
Keyword [en]
Brain aromatase; Teleost brain; Poecilia reticulata; Courtship behaviour
National Category
Zoology
Research subject
Functional Zoomorphology
Identifiers
URN: urn:nbn:se:su:diva-26902DOI: 10.1016/j.ygcen.2006.02.005OAI: oai:DiVA.org:su-26902DiVA: diva2:211715
Projects
Aromatase and androgens in fish reproductive behaviour
Available from: 2009-04-20 Created: 2009-04-17 Last updated: 2009-06-09Bibliographically approved
In thesis
1. Brain Aromatase in the guppy, Poecilia reticulata: Distribution, control and role in behaviour
Open this publication in new window or tab >>Brain Aromatase in the guppy, Poecilia reticulata: Distribution, control and role in behaviour
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Oestrogens are produced by aromatisation of androgens by the aromatase enzyme. In the vertebrate brain this synthesis has vital functions in nerve protection, cell proliferation and nerve development during injury respectively brain development. Brain oestrogens are also crucial in activating certain reproductive and aggressive behaviours in mammals and birds. Teleosts have remarkably high activity of brain aromatase (bAA) compared to mammals and birds; 100-1000 times higher in brain regions like the hypothalamus, pre-optic area and optic tectum. The role of brain oestrogens in teleost behaviour is, however, less clear than in e.g. songbirds and rodents. This thesis studies the potential role of brain aromatase and brain oestrogens in the reproductive behaviour of the guppy male (Poecilia reticulata), how guppy brain aromatase responds to steroids and is distributed in the adult brain.

The thesis shows that male behaviour can be affected by brain aromatase. Reduction of bAA by aromatase inhibitor treatment reduced the sexual behaviours sigmoid display and gonopodium swinging (I) and oestrogen receptor blocking with an oestrogen antagonist reduced the number of successful mating attempts (II). The anatomical study (IV) showed that brain aromatase is distributed in areas of the adult guppy brain that are connected to reproductive control and behaviour in vertebrates.

Guppy bAA is stimulated by both androgens and oestrogens (III) but is more sensitive to oestrogens, especially in males, and could thus be used as an indicator of endocrine disruption at low concentrations found in the environment.

The thesis can also conclude that females possess more brain aromatase than males, and that although it is expressed in the same pattern throughout the brain in both genders the enzymatic activity is differently distributed between the sexes.

Place, publisher, year, edition, pages
Stockholm: Department of Zoology, Stockholm University, 2009. 41 p.
Series
Södertörn Doctoral Dissertations, ISSN 1652-7399 ; 36
Keyword
Oestrogen production, behaviour, anatomy, endocrinology, bio markers, endocrine disruption
National Category
Microbiology
Research subject
Functional Zoomorphology
Identifiers
urn:nbn:se:su:diva-26942 (URN)978-91-86069-03-2 (ISBN)978-91-7155-870-1 (ISBN)
Public defence
2009-05-26, MA624, Södertörns högskola, Alfred Nobels allé 7, Huddinge, 10:00 (English)
Opponent
Supervisors
Projects
Aromatase and androgens in fish reproductive behaviour
Available from: 2009-05-05 Created: 2009-04-20 Last updated: 2009-06-09Bibliographically approved

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