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Retrograde axonal transport and motor neuron disease
University of Kentucky, USA.ORCID iD: 0000-0002-8630-2127
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2008 (English)In: Journal of Neurochemistry, ISSN 0022-3042, E-ISSN 1471-4159, Vol. 106, no 2, 495-505 p.Article in journal (Refereed) Published
Abstract [en]

Transport of material between extensive neuronal processes and the cell body is crucial for neuronal function and survival. Growing evidence shows that deficits in axonal transport contribute to the pathogenesis of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Here we review recent data indicating that defects in dynein-mediated retrograde axonal transport are involved in ALS etiology. We discuss how mutant copper-zinc superoxide dismutase (SOD1) and an aberrant interaction between mutant SOD1 and dynein could perturb retrograde transport of neurotrophic factors and mitochondria. A possible contribution of axonal transport to the aggregation and degradation processes of mutant SOD1 is also reviewed. We further consider how the interference with axonal transport and protein turnover by mutant SOD1 could influence the function and viability of motor neurons in ALS.

Place, publisher, year, edition, pages
2008. Vol. 106, no 2, 495-505 p.
National Category
Neurosciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-27159DOI: 10.1111/j.1471-4159.2008.05393.xPubMedID: 18384644OAI: oai:DiVA.org:su-27159DiVA: diva2:212802
Available from: 2009-04-23 Created: 2009-04-23 Last updated: 2017-12-13Bibliographically approved

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